TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) accumulate in tumors and the peripheral blood
of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A …
of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A …
TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
T Spinetti, L Spagnuolo, I Mottas, C Secondini… - …, 2016 - Taylor & Francis
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature
myeloid cells with the capacity to inhibit immunological responses. During cancer …
myeloid cells with the capacity to inhibit immunological responses. During cancer …
Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells
J Wang, Y Shirota, D Bayik, H Shirota… - The Journal of …, 2015 - journals.aai.org
Tumors persist by occupying immunosuppressive microenvironments that inhibit the activity
of tumoricidal T and NK cells. Monocytic myeloid-derived suppressor cells (mMDSC) are an …
of tumoricidal T and NK cells. Monocytic myeloid-derived suppressor cells (mMDSC) are an …
Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells
M Lee, CS Park, YR Lee, SA Im, S Song… - Archives of pharmacal …, 2014 - Springer
Myeloid-derived suppressor cells (MDSCs) accumulate in cancer patients and tumor-
bearing mice, subsequently suppressing the host immune system. MDSCs represent a …
bearing mice, subsequently suppressing the host immune system. MDSCs represent a …
TLR4 signaling in cancer cells promotes chemoattraction of immature dendritic cells via autocrine CCL20
L Wang, Q Liu, Q Sun, C Zhang, T Chen… - … and biophysical research …, 2008 - Elsevier
Toll-like receptors (TLRs) are involved in the production of inflammatory mediators upon
specific ligands stimuli. Chemokines are important inflammatory mediators capable of …
specific ligands stimuli. Chemokines are important inflammatory mediators capable of …
Antitumor activity of TLR7 is potentiated by CD200R antibody leading to changes in the tumor microenvironment
Z Pilch, K Tonecka, A Braniewska, Z Sas… - Cancer immunology …, 2018 - AACR
Stimulation of Toll-like receptor 7 (TLR7) activates myeloid cells and boosts the immune
response. Previously, we have shown that stimulation of the inhibitory CD200 receptor …
response. Previously, we have shown that stimulation of the inhibitory CD200 receptor …
TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity
D Bogunovic, O Manches, E Godefroy, A Yewdall… - Cancer research, 2011 - AACR
Toll-like receptor (TLR) agonists are promising adjuvants for immune therapy of cancer, but
their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here …
their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here …
[HTML][HTML] The TLR7 agonist induces tumor regression both by promoting CD4+ T cells proliferation and by reversing T regulatory cell-mediated suppression via …
C Wang, Q Zhou, X Wang, X Wu, X Chen, J Li, Z Zhu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Treg-induced immunosuppression is now recognized as a key element in enabling tumors
to escape immune-mediated destruction. Although topical TLR7 therapies such as …
to escape immune-mediated destruction. Although topical TLR7 therapies such as …
TLR1/TLR2 signaling blocks the suppression of monocytic myeloid-derived suppressor cell by promoting its differentiation into M1-type macrophage
Y Deng, J Yang, J Qian, R Liu, E Huang, Y Wang… - Molecular …, 2019 - Elsevier
Myeloid derived suppressor cells (MDSCs) play a key role in tumor immunosuppressive
microenvironment, which helps tumors avoid immune destruction. Blocking the suppressive …
microenvironment, which helps tumors avoid immune destruction. Blocking the suppressive …
Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived …
H Shime, A Maruyama, S Yoshida, Y Takeda… - …, 2018 - Taylor & Francis
ABSTRACT CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) suppress
activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs …
activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs …