XPA: DNA repair protein of significant clinical importance
L Borszéková Pulzová, TA Ward… - International journal of …, 2020 - mdpi.com
The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …
A human XPC protein interactome—a resource
A Lubin, L Zhang, H Chen, VM White… - International journal of …, 2013 - mdpi.com
Global genome nucleotide excision repair (GG-NER) is responsible for identifying and
removing bulky adducts from non-transcribed DNA that result from damaging agents such as …
removing bulky adducts from non-transcribed DNA that result from damaging agents such as …
The role of XPC: implications in cancer and oxidative DNA damage
JPM Melis, M Luijten, LHF Mullenders… - … Research/Reviews in …, 2011 - Elsevier
The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to
cell death, accelerated aging features and cancer. One of the most versatile and important …
cell death, accelerated aging features and cancer. One of the most versatile and important …
[HTML][HTML] Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53 …
Nucleotide excision repair (NER) and ataxia telangiectasia mutated (ATM)/ATR (ATM-and
RAD3-related) DNA damage checkpoints are among the major pathways that affect the …
RAD3-related) DNA damage checkpoints are among the major pathways that affect the …
Defining the function of XPC protein in psoralen and cisplatin-mediated DNA repair and mutagenesis
Z Chen, XS Xu, J Yang, G Wang - Carcinogenesis, 2003 - academic.oup.com
DNA damage recognition plays an important role in DNA repair and mutagenesis. Failure to
recognize DNA damage may lead to DNA replication without damage repair as well as …
recognize DNA damage may lead to DNA replication without damage repair as well as …
[HTML][HTML] Transcriptional consequences of XPA disruption in human cell lines
M Manandhar, MG Lowery, KS Boulware, KH Lin, Y Lu… - DNA repair, 2017 - Elsevier
Nucleotide excision repair (NER) in mammalian cells requires the xeroderma pigmentosum
group A protein (XPA) as a core factor. Remarkably, XPA and other NER proteins have been …
group A protein (XPA) as a core factor. Remarkably, XPA and other NER proteins have been …
Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair
Xeroderma pigmentosum group G (XPG) protein is a structure-specific repair endonuclease,
which cleaves DNA strands on the 3′ side of the DNA damage during nucleotide excision …
which cleaves DNA strands on the 3′ side of the DNA damage during nucleotide excision …
A new structural insight into XPA–DNA interactions
B Hilton, N Shkriabai, PR Musich… - Bioscience …, 2014 - portlandpress.com
XPA (xeroderma pigmentosum group A) protein is an essential factor for NER (nucleotide
excision repair) which is believed to be involved in DNA damage recognition/verification …
excision repair) which is believed to be involved in DNA damage recognition/verification …
Identification of Novel Small Molecule Inhibitors of the XPA Protein Using in Silico Based Screening
The nucleotide excision repair pathway catalyzes the removal of bulky adduct damage from
DNA and requires the activity of more than 30 individual proteins and complexes. A diverse …
DNA and requires the activity of more than 30 individual proteins and complexes. A diverse …
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
Nucleotide excision repair (NER) is the most versatile DNA repair system that removes bulky
DNA damage induced by various endogenous and exogenous factors, including UV …
DNA damage induced by various endogenous and exogenous factors, including UV …