Cancer therapy is one of the most important challenges of modern medical and chemical
sciences. Among the many methods of combating cancer, chemotherapy plays a special …

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in
women. The impact of the new pyrazolo [4, 3-e] tetrazolo [1, 5-b][1, 2, 4] triazine …

This study aimed to develop novel 1, 3, 5‐triazine derivatives as potent anti‐cervical cancer
agents. The compounds were synthesized in short steps with an excellent yield and …

In the search for new compounds with antitumor activity, new potential anticancer agents
were designed as molecular hybrids containing the structures of a triazine ring and a …

Sulfonamide group is a magic group introduced as the main core for different bioactivities in
drug industry. Pharmacologically and according to its substitution, sulfonamide derivatives …

Sulfonamides are the first effective chemotherapeutic agents used for several years to cure
or prevent systemic bacterial infections. In addition, this agents showed anti-carbonic …

With the expectation to find out new anti-gastric cancer agents with high efficacy and
selectivity, a series of novel tertiary sulfonamide derivatives were synthesized and the anti …

In this study, we synthesized novel sulfonamides with a 1, 2, 4-triazine moiety according to
pharmacophore requirements for biological activity. All the synthesized compounds were …

Abstract Carbonic anhydrases (CA I, II, IX and XII) are known to be highly expressed in
various human malignancies. CA IX is overexpressed in colorectal cancer specifically in …

In this study, we designed and synthesized a series of 1, 4-benzothiazine and evaluated
them for anticancer activity toward HT-29 human colon cancer cells using SRB assay …