Behavioral neuroscience tests such as the Light/Dark Test, the Open Field Test, the Elevated
Plus Maze Test, and the Three Chamber Social Interaction Test have become both essential …

Anxiety is a widely studied phenomenon in behavioral neuroscience, but the recent
literature lacks an overview of the major conceptual framework underlying anxiety research …

Behavioral tests of animals in a controlled experimental setting provide a valuable tool to
advance understanding of genotype-phenotype relations, and to study the effects of genetic …

Anxiety is widely conceptualized as a state of heightened distress, arousal, and vigilance
that can be elicited by potential threat (1, 2). When extreme or pervasive, anxiety can be …

The combination of cutting-edge molecular technology and high-throughput phenotyping
tools will not bring the expected contribution to the pre-clinical study of anxiety if not …

The light/dark transition test (LDT) is one of the most widely used tests to measure anxiety-
like behavior in mice. The test is based on the natural aversion of mice to brightly illuminated …

Rationale Anxiety, a negative state of high arousal and vigilance, is especially prevalent in
women, making identification of underlying mechanisms critical for developing effective …

Background Knowledge on the neurobiological systems underlying psychiatric disorders
has considerably evolved due to findings on basic research using animal models. Anxiety …

Neuropsychiatric research has utilized cognitive testing in rodents to improve our
understanding of cognitive deficits and for preclinical drug development. However, more …

Publisher Summary The pharmaceutical industry and academia are engaged in enormous
investments in developing novel pharmacotherapeutics for anxiety disorders. However …