An ideal nanocarrier for efficient drug delivery must be able to target specific cells and carry
high doses of therapeutic drugs and should also exhibit optimized physicochemical …

Ferritin (FRT) is a major iron storage protein found in humans and most living organisms.
Each ferritin is composed of 24 subunits, which self-assemble to form a cage-like …

Human ferritin heavy chain (HFt) has been demonstrated to possess considerable potential
for targeted delivery of drugs and diagnostic agents to cancer cells. Here, we report the …

Ferritin, a widely expressed iron binding protein, has emerged as a promising drug delivery
vehicle due to its unique architecture, intrinsic tumor targeting property, and excellent …

Rationale: With the advantages of tumor-targeting, pH-responsive drug releasing, and
biocompatibility, ferritin nanocage emerges as a promising drug carrier. However, its wide …

A genetically engineered apoferritin variant consisting of 24 heavy-chain subunits (HFn) was
produced to achieve a cumulative delivery of an antitumor drug, which exerts its cytotoxic …

Ferritins are spherical iron storage proteins within cells, composed of 24 subunits of two
types, heavy-chain ferritin (HFn) and light-chain ferritin. Ferritins auto-assemble naturally …

Ferritin is an iron storage protein that plays a key role in iron homeostasis and anti-oxidation
of cells. Due to its unique architecture of 24 self-assembling subunits and hollow cavity …

Conventionally, a disassembly and reassembly method has been used for encapsulation of
drug molecules in ferritin protein nano-cages. However, clinical applications of ferritin have …

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer deaths,
primarily due to its high incidence of recurrence and metastasis. Considerable efforts have …