Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective
tissue diseases, specifically characterized by vascular abnormalities and inflammatory and …

Systemic sclerosis (SSc) is a clinically heterogeneous orphan disease of unknown etiology
and no effective therapy. It is characterized by protean manifestations, an unpredictable …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by the
presence of three main actors: vasculopathy, immune activation, and fibrosis. This …

Systemic sclerosis (SSc) is a complex autoimmune disease in which immune activation,
vasculopathy, and extensive fibrosis of the skin and internal organs are among the principal …

Systemic sclerosis (SSc) is an autoimmune disease which is characterized by vasculopathy,
tissue fibrosis and activation of the innate and adaptive immune system. Clinical features of …

Systemic sclerosis (SSc) is a rare chronic disease of unknown etiology characterized by
vascular abnormalities and fibrosis involving the skin and internal organs, especially the …

The concept of personalized medicine has led to a paradigm shift in recent years. It
integrates multiple clinical and biological levels of investigation aimed at offering the best …

Systemic sclerosis (SSc), a complex multi-systemic disease characterized by immune
dysregulation, vasculopathy and fibrosis, is associated with high mortality. Its pathogenesis …

Systemic sclerosis (SSc) is a rare and chronic autoimmune disease characterized by a
pathogenic triad of immune dysregulation, vasculopathy, and progressive fibrosis. Clinical …

Systemic sclerosis (SSc) is a multisystem chronic disease characterized by the three
cardinal pathological features, including autoimmunity/inflammation, vasculopathy, and …