TLR4-MyD88-NF-κB signaling imbalances Th17 and Treg cells in thymoma with myasthenia gravis.

RY Zhang, XS Zhang, C Lu, ZR Wang… - … Review for Medical …, 2023 - search.ebscohost.com
OBJECTIVE: Thymus is an immune organ in which pathological changes may cause
autoimmune diseases, including myasthenia gravis (MG). Recent studies have focused on …

Imbalance of Th17 and Tregs in thymoma may be a pathological mechanism of myasthenia gravis

Y Chen, XS Zhang, YG Wang, C Lu, J Li, P Zhang - Molecular Immunology, 2021 - Elsevier
An imbalance in Th17 cells and Tregs may be an important cause of the pathogenesis of
thymoma with myasthenia gravis (MG). In this study, 30 patients with simple thymoma and …

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis

İ Altınönder, M Kaya, SP Yentür, A Çakar… - Journal of …, 2024 - Springer
Myasthenia gravis (MG) is an immune-mediated disease frequently associated with thymic
changes. Increased T helper 17 (Th17) cell activity and dysfunctional regulatory T (Treg) …

LncRNA XLOC_003810 modulates thymic Th17/Treg balance in myasthenia gravis with thymoma

L Niu, J Jiang, Y Yin, B Hu - Clinical and Experimental …, 2020 - Wiley Online Library
Imbalance of T helper 17 (Th17)/regulatory T (Treg) cells is involved in the pathogenesis of
myasthenia gravis with thymoma (MG‐T). Long non‐coding RNAs (lncRNAs) are implicated …

Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity

C Cordiglieri, R Marolda, S Franzi, C Cappelletti… - Journal of …, 2014 - Elsevier
The thymus is the main site of immune sensitization to AChR in myasthenia gravis (MG). In
our previous studies we demonstrated that Toll-like receptor (TLR) 4 is over-expressed in …

Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution

P Bernasconi, M Barberis, F Baggi, L Passerini… - The American journal of …, 2005 - Elsevier
Thymic abnormalities are present in∼ 80% of myasthenia gravis (MG) patients, and the
thymus seems to be the main site of autosensitization to the acetylcholine receptor. In view …

T helper type 17 cells expand in patients with myasthenia‐associated thymoma

Z Wang, W Wang, Y Chen, D Wei - Scandinavian journal of …, 2012 - Wiley Online Library
Myasthenia gravis (MG) is a prototypical CD4+ T cell–dependent autoimmune disease
mediated by anti‐acetylcholine receptor autoantibodies (AChR‐Abs). Certain subsets of …

Thymoma T helper type 17 cells and related cytokines in myasthenia gravis

ZK Wang, W Wang, YP Chen, DN Wei - Zhonghua nei ke za zhi, 2012 - europepmc.org
Objective To investigate the immunoregulatory role of Th17 cell and the related cytokines in
myasthenia gravis. Methods Totally 51 myasthenia gravis (MG) patients were divided into …

Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin

Z Wang, J Wang, B Deng, S Ding, T Wu - Journal of Medical Colleges of …, 2009 - Elsevier
OBJECTIVE: To investigate the expression of both thymic regulatory T cells (CD4+ CD25+
Foxp3+ cells, Treg) and thymic stromal lymphopoietin (TSLP) in thymomas accompanying …

Increased proportion of Tc17 and Th17 cells and their significant reduction after thymectomy may be related to disease progression in myasthenia gravis

M Hosseini, B Robat-Jazi, V Shaygannejad… - …, 2018 - karger.com
Objective: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies
against the neuromuscular junction. The thymus has an important role in the pathogenesis …