Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …

Successful human reproduction requires gamete maturation, fertilization, and early
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …

About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Our understanding of reproduction and early embryonic development has directly enabled
our manipulation of the mouse genome for tests of gene function in vivo. In this review, we …

Ovarian failure leading to infertility can be caused by improper prenatal development of the
fetal gonad or disruption of the complex postnatal process of folliculogenesis due to …

To show that disruption of meiotic competence results in cell cycle arrest, and the production
of immature oocytes that are not capable of fertilization. Through an extensive review of …

Primary ovarian insufficiency (POI), also known as premature ovarian failure, is a form of
hypergonadotropic hypogonadism that causes infertility in~ 1% of women< 40 years of age …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

Ovarian follicle development is a complex process that begins with the establishment of
what is thought to be a finite pool of primordial follicles and culminates in either the atretic …

STUDY QUESTION Is it possible to identify new mutations potentially associated with non-
syndromic primary ovarian insufficiency (POI) via whole-exome sequencing (WES) …