The liver is the most important organ for biological transformation in the body and is crucial
for maintaining the body's vital activities. Liver injury is a serious pathological condition that …

Introduction Liver is the largest and important organ in the body, involved in the metabolism
of food and drugs. Liver diseases are potentially life threatening for humans. The etiology of …

Numerous factors, including exposure to harmful substances, drinking too much alcohol,
contracting certain hepatitis serotypes, and using specific medicines, contribute to the …

The liver is among the most complex and important organs in the human body.
Hepatotoxicity is a leading cause of morbidity and mortality, and its prevalence is …

Drug‐induced liver injury (DILI) is a major concern in clinical studies as well as in
postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough …

The liver is one of the most important organs of the human body, with a variety of complex
functions including synthesis, detoxification, metabolism, secretion, biotransformation, and …

Animal models are indispensable for the elucidation of pathogenesis mechanisms, the
identification of potential therapeutic targets, and the development of novel therapies for …

Background: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure
cases in the United States, and remains a common cause of withdrawal of drugs in both …

In order to foster animal welfare as well as high quality of research, many countries regulate
by law that the severity of animal experiments must be evaluated and considered when …

Both acute and chronic liver diseases are frequent and potentially lethal conditions.
Development of new therapeutic strategies and drugs depends on understanding of liver …