Appropriate regulation of the inflammatory response is essential for survival. Interleukin-10
(IL-10), a well-known anti-inflammatory cytokine, plays a major role in controlling …

Resident cells of the central nervous system (CNS) play an important role in detecting insults
and initiating protective or sometimes detrimental host immunity. At peripheral sites, immune …

Anti-inflammatory cytokine interleukin (IL)-10 is pivotal for limiting excessive inflammation in
the central nervous system. Reports show that lipopolysaccharide (LPS)-induced microglial …

Abstract Interleukin (IL)‐10, a prototypical anti‐inflammatory cytokine, has been shown to
provide beneficial effects in neuronal injury in vivo but the full range of actions has not been …

Interleukins 1α and 1β (IL‐1) are very potent signaling molecules that are expressed
normally at low levels, but are induced rapidly in response to local or peripheral insults. IL‐1 …

The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

Microglia represent the primary resident immune cells of the central nervous system (CNS)
and modulate local immune responses. Depending on their physiological functions …

Background The inflammatory response is critical to fight insults, such as pathogen invasion
or tissue damage, but if not resolved often becomes detrimental to the host. A growing body …

Summary Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic
processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 …

Chemokine receptors, a family of Gi protein-coupled receptors responsible for cell migration,
are widely expressed by cells of immune and nervous systems. Activation of receptors on …