In self-renewing tissues, cell lineages consisting of stem cell and classes of daughter cells
are the basic units which are responsible for the correct functioning of the organ. Cell …

Tissue development and homeostasis are thought to be regulated endogenously by control
loops that ensure that the numbers of stem cells and daughter cells are maintained at …

Understanding the dynamics of stem cell lineages is of central importance both for healthy
and cancerous tissues. We study stochastic population dynamics of stem cells and …

Tissues are maintained by adult stem cells that self-renew and also differentiate into
functioning tissue cells. Homeostasis is achieved by a set of complex mechanisms that …

Stem cells dynamics is an important field of research with promising clinical impacts. Due to
the revolutionary new technologies of biological data collection, an enormous amount of …

Differentiation and self-renewal of stem cells is an essential process for the maintenance of
tissue composition. The promise of novel medical therapies combined with the complexity of …

Recent discovery of cancer stem cells in tumorigenic tissues has raised many questions
about their nature, origin, function and their behavior in cell culture. Most of current …

The ability of a few stem-cells to repopulate a severely damaged bone marrow (BM)
guarantees the stability of our physical existence, and facilitates successful BM …

One purpose of mathematical models in cell biology is to illustrate and support theoretical
arguments, eg evaluating alternative modes of regulation in complex systems. Since it is not …

A general model of cell populations including differentiation is presented. The existence of
linear feedback-relations between the stem-cell and the mature cell demes controlling the …