Gene expression is controlled by the involvement of gene-proximal (promoters) and distal
(enhancers) regulatory elements. Our previous results demonstrated that a subset of gene …

Enhancers determine tissue-specific gene expression programs. Enhancers are marked by
high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300 …

Background Macrophages are sentinel cells essential for tissue homeostasis and host
defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in …

In cells of the immune system, inflammatory stimuli trigger highly coordinated cascades of
gene activation that are precisely calibrated to the nature and strength of the stimulus …

The specific binding of transcription factors to cognate sequence elements is thought to be
critical for the generation of specific gene expression programs. Members of the nuclear …

Transcript elongation by polymerase II paused at the Egr1 promoter is activated by mitogen-
activated protein kinase phosphorylation of the ternary complex factor (TCF) ELK1 bound at …

Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …

The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation,
however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse …

Ets proteins are a family of transcription factors that regulate the expression of a myriad of
genes in a variety of tissues and cell types. This functional versatility emerges from their …

Most well-characterized enhancers are deeply conserved. In contrast, genome-wide
comparative studies of steady-state systems showed that only a small fraction of active …