Therapeutic success of anti-HIV therapies is limited by the development of drug resistant
viruses. These genetic variants display complex mutational patterns in their pol gene, which …

Drug resistance testing has been shown to be beneficial for clinical management of HIV type
1 infected patients. Whereas phenotypic assays directly measure drug resistance, the …

The calibrated population resistance (CPR) tool is a web-accessible program for performing
standardized genotypic estimation of transmitted HIV-1 drug resistance. The program is …

Understanding the genetic basis of HIV-1 drug resistance is essential to developing new
antiretroviral drugs and optimizing the use of existing drugs. This understanding, however, is …

Objectives The development of a genotypic drug resistance interpretation algorithm, and the
evaluation of its power to predict therapy outcome. Design A rule-based algorithm was …

Background Growing evidence has linked HIV-1 resistance mutations and drug failure. The
use of genotypic-resistance analysis to assist therapeutic decision-making in patients failing …

Linear regression modeling on a database of HIV-1 genotypes and phenotypes was applied
to predict the HIV-1 resistance phenotype from the viral genotype. In this approach, the …

Objectives The aim of this study was to assess the concordance on the interpretation of HIV‐
1 drug‐resistance genotypic data by three widely used algorithms: Stanford University …

Background. The prevalence of drug resistance among persons with newly acquired human
immunodeficiency virus (HIV) infection is well documented. However, it is unclear to what …

Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment.
Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1 …