New approaches to control the spread of tuberculosis (TB) are needed, including tools to
predict development of active TB from latent TB infection (LTBI). Recent studies have …

Transcriptional biomarkers for predicting development of tuberculosis: progress and clinical
considerations | European Respiratory Society Skip to main content Main menu Home Current …

In humans, Mycobacterium tuberculosis persists for long periods in a clinically latent state,
creating a huge reservoir of'silent'tuberculosis (TB)(roughly one-third of the global …

Mycobacterium tuberculosis (MTB) infection, IFN-is an important mediator of macrophage
activation [1]. Mice deficient in the gene for IFN-are susceptible to fatal tuberculosis (TB)[1 …

It is generally thought that Mycobacterium tuberculosis (Mtb)-specific CD4+ Th1 cells
producing IFN-γ are essential for protection against tuberculosis (TB). In some studies …

Background Multiple blood transcriptional signatures have been proposed for identification
of active and incipient tuberculosis. We aimed to compare the performance of systematically …

Due to the failure of chemotherapy and the only available vaccine, BCG, to control
tuberculosis (TB) disease, there is an urgent need to develop new vaccines and …

Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M.
tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may …

Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …

Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …