Dysregulation and therapeutic targeting of RNA splicing in cancer
RF Stanley, O Abdel-Wahab - Nature cancer, 2022 - nature.com
High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …
Aberrant RNA splicing in cancer
L Escobar-Hoyos, K Knorr… - Annual review of cancer …, 2019 - annualreviews.org
RNA splicing, the enzymatic process of removing segments of premature RNA to produce
mature RNA, is a key mediator of proteome diversity and regulator of gene expression …
mature RNA, is a key mediator of proteome diversity and regulator of gene expression …
Aberrant RNA splicing and therapeutic opportunities in cancers
H Yamauchi, K Nishimura, A Yoshimi - Cancer science, 2022 - Wiley Online Library
There has been accumulating evidence that RNA splicing is frequently dysregulated in a
variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 …
variety of cancers and that hotspot mutations affecting key splicing factors, SF3B1, SRSF2 …
RNA splicing dysregulation and the hallmarks of cancer
RK Bradley, O Anczuków - Nature Reviews Cancer, 2023 - nature.com
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Cancer-associated splicing alterations arise from both recurrent mutations and altered …
Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets
RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates
that splicing defects resulting from splicing dysregulation play critical roles in cancer …
that splicing defects resulting from splicing dysregulation play critical roles in cancer …
Alternative‐splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
LM Urbanski, N Leclair… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
A Sveen, S Kilpinen, A Ruusulehto, RA Lothe… - Oncogene, 2016 - nature.com
Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …
Alternative splicing in cancer: noise, functional, or systematic?
RI Skotheim, M Nees - The international journal of biochemistry & cell …, 2007 - Elsevier
Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …
variants from individual genes. Various cell types and developmental stages regulate …
Splicing-factor alterations in cancers
O Anczuków, AR Krainer - Rna, 2016 - rnajournal.cshlp.org
Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …
regulatory elements or changes in components of the splicing machinery. This review …
The emerging role of splicing factors in cancer
AR Grosso, S Martins, M Carmo‐Fonseca - EMBO reports, 2008 - embopress.org
Recent progress in global sequence and microarray data analysis has revealed the
increasing complexity of the human transcriptome. Alternative splicing generates a huge …
increasing complexity of the human transcriptome. Alternative splicing generates a huge …
相关搜索
- therapeutic targeting rna splicing
- splicing regulators cancer therapeutics
- expression changes rna splicing
- splicing dysregulation mechanistic understanding
- driver mutations rna splicing
- mechanistic understanding therapeutic targets
- splicing dysregulation therapeutic targets
- therapeutic opportunities rna splicing