[HTML][HTML] Largest GWAS of PTSD (N= 20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Abstract The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
PTSD) combined genome-wide case–control molecular genetic data across 11 multiethnic …
[HTML][HTML] The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: posttraumatic stress disorder enters the age of large-scale genomic …
MW Logue, AB Amstadter, DG Baker… - …, 2015 - nature.com
The development of posttraumatic stress disorder (PTSD) is influenced by genetic factors.
Although there have been some replicated candidates, the identification of risk variants for …
Although there have been some replicated candidates, the identification of risk variants for …
Genomic approaches to posttraumatic stress disorder: the psychiatric genomic consortium initiative
Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly
prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent …
prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent …
The genetics and epigenetics of PTSD: overview, recent advances, and future directions
Highlights•Over 100 candidate gene studies have been conducted to date.•Candidate gene
studies of the HPA-axis system appear to be promising.•Genome-wide association studies …
studies of the HPA-axis system appear to be promising.•Genome-wide association studies …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
B Devlin, JR Kelsoe, P Sklar, MJ Daly, MC O'Donovan… - Nature …, 2013 - nature.com
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …
Genome-wide association studies of posttraumatic stress disorder in 2 cohorts of US Army soldiers
Importance Posttraumatic stress disorder (PTSD) is a prevalent, serious public health
concern, particularly in the military. The identification of genetic risk factors for PTSD may …
concern, particularly in the military. The identification of genetic risk factors for PTSD may …
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Objective: Family and twin studies indicate substantial overlap of genetic influences on
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies
Post-traumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder that
constitutes a major health care burden. Despite evidence supporting a genetic …
constitutes a major health care burden. Despite evidence supporting a genetic …