COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer
RJ Fagan, AK Dingwall - Cancer letters, 2019 - Elsevier
The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential
roles in regulating developmental pathways, and mutations in the genes encoding these …
roles in regulating developmental pathways, and mutations in the genes encoding these …
The cancer COMPASS: navigating the functions of MLL complexes in cancer
DJ Ford, AK Dingwall - Cancer genetics, 2015 - Elsevier
The mixed-lineage leukemia family of histone methyltransferases (MLL1–4, or KMT2A–D)
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …
MLL5 (KMT2E): structure, function, and clinical relevance
X Zhang, W Novera, Y Zhang, LW Deng - Cellular and molecular life …, 2017 - Springer
The mixed lineage leukemia (MLL) family of genes, also known as the lysine N-
methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax …
methyltransferase 2 (KMT2) family, are homologous to the evolutionarily conserved trithorax …
[HTML][HTML] KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
Abstract KMT2D (lysine (K)-specific methyltransferase 2D), formerly named MLL2
(myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone …
(myeloid/lymphoid or mixed-lineage leukemia 2, also known as ALR/MLL4), is a histone …
[HTML][HTML] Diverse functions of PHD fingers of the MLL/KMT2 subfamily
M Ali, RA Hom, W Blakeslee, L Ikenouye… - … Et Biophysica Acta (BBA …, 2014 - Elsevier
Five members of the KMT2 family of lysine methyltransferases, originally named the mixed
lineage leukemia (MLL1-5) proteins, regulate gene expression during embryogenesis and …
lineage leukemia (MLL1-5) proteins, regulate gene expression during embryogenesis and …
[HTML][HTML] Why are so many MLL lysine methyltransferases required for normal mammalian development?
NT Crump, TA Milne - Cellular and Molecular Life Sciences, 2019 - Springer
The mixed lineage leukemia (MLL) family of proteins became known initially for the
leukemia link of its founding member. Over the decades, the MLL family has been …
leukemia link of its founding member. Over the decades, the MLL family has been …
[HTML][HTML] Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors
SS Dhar, MG Lee - Oncotarget, 2021 - ncbi.nlm.nih.gov
Epigenetic mechanisms are central to understanding the molecular basis underlying
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …
[HTML][HTML] UTX mutations in human cancer
L Wang, A Shilatifard - Cancer cell, 2019 - cell.com
Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by
KDM6A) is a histone demethylase that targets di-and tri-methylated histone H3 lysine 27 …
KDM6A) is a histone demethylase that targets di-and tri-methylated histone H3 lysine 27 …
Mixed lineage leukemia: a structure–function perspective of the MLL1 protein
MS Cosgrove, A Patel - The FEBS journal, 2010 - Wiley Online Library
Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in
the human mixed lineage leukemia protein‐1 (MLL1) gene. MLL1 is a member of the …
the human mixed lineage leukemia protein‐1 (MLL1) gene. MLL1 is a member of the …