Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies
Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …
Neuroprotective strategies for traumatic brain injury: improving clinical translation
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …
Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?
D Lerouet, C Marchand‐Leroux… - Fundamental & clinical …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …
cause of death and disability in individuals, contributing to devastating socioeconomic …
Neuroprotection and traumatic brain injury: the search continues
AI Faden - Archives of neurology, 2001 - jamanetwork.com
During the last decade, experimental studies of traumatic brain injury (TBI) have pro-vided
important new insights into the pathophysiological mechanisms leading to post-traumatic …
important new insights into the pathophysiological mechanisms leading to post-traumatic …
Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature
JW Schouten - Current opinion in critical care, 2007 - journals.lww.com
Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …
Neuroprotection for traumatic brain injury
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …
Exploring new routes for neuroprotective drug development in traumatic brain injury
T Janowitz, DK Menon - Science translational medicine, 2010 - science.org
Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a
substantial predicted increase in incidence. Despite an obvious need, there are no …
substantial predicted increase in incidence. Despite an obvious need, there are no …
Emerging treatments for traumatic brain injury
Y Xiong, A Mahmood, M Chopp - Expert opinion on emerging drugs, 2009 - Taylor & Francis
Background: This review summarizes promising approaches for the treatment of traumatic
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …
Critical appraisal of neuroprotection trials in head injury: what have we learned?
CM Tolias, MR Bullock - NeuroRx, 2004 - Springer
To date, despite very encouraging preclinical results, almost all phase II/III clinical
neuroprotection trials in traumatic brain injury (TBI) have failed to show any consistent …
neuroprotection trials in traumatic brain injury (TBI) have failed to show any consistent …
Animal models of traumatic brain injury
Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …
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