The extent to which early events shape tumor evolution is largely uncharacterized, even
though a better understanding of these early events may help identify key vulnerabilities in …

Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic
progression remain poorly understood. We isolated pure populations of cancer cells from …

Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …

Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early
invasion and refractory relapse after initial treatment response. Although these aggressive …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective
treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and …

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor type that is
typically metastatic upon diagnosis. We have a poor understanding of the factors that control …

Small cell lung cancer (SCLC) is the lung neoplasia with the poorest prognosis, due to its
high metastatic potential and chemoresistance upon relapse. Using the previously …

Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a
single entity with predictably poor results. Using tumor expression data and non-negative …

Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …

Metastasis is a major cause of morbidity and mortality in cancer patients. However, the
molecular and cellular mechanisms underlying the ability of cancer cells to metastasize …