Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

M Ashrafizadeh, Z Ahmadi… - Current Molecular …, 2020 - ingentaconnect.com
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma
longa (turmeric). This medicinal compound has different biological activities, including …

Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications

M Rahban, M Habibi-Rezaei, M Mazaheri, L Saso… - Antioxidants, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that
maintains the cell's redox balance state and reduces inflammation in different adverse …

Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects

SH Shahcheraghi, F Salemi, N Peirovi, J Ayatollahi… - Molecules, 2021 - mdpi.com
Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein
(bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 …

The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications

S Ghareghomi, M Rahban, Z Moosavi-Movahedi… - Molecules, 2021 - mdpi.com
Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …

Curcumin attenuates oxidative stress in RAW264. 7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway

X Lin, D Bai, Z Wei, Y Zhang, Y Huang, H Deng… - PloS one, 2019 - journals.plos.org
Large-scale breeding environments often lead to oxidative stress. Macrophages play an
important role in the immune system and are vulnerable to reactive oxygen species (ROS) …

Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351

JY Park, HY Sohn, YH Koh, C Jo - Scientific Reports, 2021 - nature.com
Curcumin, a phytochemical extracted from Curcuma longa rhizomes, is known to be
protective in neurons via activation of Nrf2, a master regulator of endogenous defense …

Curcumin regulates cancer progression: Focus on ncRNAs and molecular signaling pathways

H Wang, K Zhang, J Liu, J Yang, Y Tian, C Yang… - Frontiers in …, 2021 - frontiersin.org
Curcumin [(1E, 6E)‑1, 7‑bis (4‑hydroxy‑3‑methoxyphenyl) hepta‑1, 6‑diene‑3, 5‑dione] is a
natural polyphenol derived from the rhizome of the turmeric plant Curcuma longa …

Molecular mechanisms of curcumin action: signal transduction

A Shehzad, YS Lee - Biofactors, 2013 - Wiley Online Library
Chemoprevention represents one of the most highly effective anti‐cancer strategies and is
accompanied by minimal secondary effects as compared to conventional chemotherapies …

Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

P Liczbiński, J Michałowicz… - Phytotherapy …, 2020 - Wiley Online Library
Recently, many studies have been conducted trying to explain the molecular mechanism of
curcumin action in various pathological states of the cell and the organism. Curcumin is …

[HTML][HTML] Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future …

MR Islam, A Rauf, S Akash, SI Trisha, AH Nasim… - Biomedicine & …, 2024 - Elsevier
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin
(diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used …