Le récepteur Fas (CD95) et son ligand FasL (CD95-L) jouent un rôle clé dans la mort des
lymphocytes T. Alors que la caspase-8 a été montrée comme essentielle dans l'apoptose …

Engagement of the Fas receptor promotes apoptosis by activation of caspases. In addition,
alterations in plasma membrane lipid orientation and intracellular ceramide levels are often …

Tumor necrosis factor α (TNF) or cytotoxic anti-Fas antibodies lead to the activation of
apoptotic proteases (caspases) and to sphingomyelinase-mediated ceramide generation …

Far, receptor-induced apoptosis plays critical roles in immune homeostasis. However, moet
of the signal transduction events distal to Fas ligation have not been elucidated. Here, we …

Ceramides deriving from sphingomyelin hydrolysis are important mediators of apoptotic
signals originating from Fas (APO-1/CD95). However, definitive evidence for the role played …

Apoptosis plays an essential role in atherosclerosis. Oxidized low‐density lipoproteins
(oxLDL) and activated T lymphocytes are present in atherosclerotic lesions, and we have …

Ceramide has been suggested as the secondary messenger mediating the apoptotic signal
for Fas engagement. By using different inhibitors, we demonstrated here that ceramide is …

Since its discovery, caspase-8 has been placed at the apex of the proteolytic cascade
triggered by death receptor (DR) cross-linking. Because of its capacity to interact with the …

We investigated whether cell-permeable, synthetic ceramide (C6 ceramide) could induce
apoptosis in Fas-resistant Hodgkin's disease (HD)-derived cell lines. Despite strongly …

Recent studies suggest that trimerization of Fas is insufficient for apoptosis induction and
indicate that super-aggregation of trimerized Fas might be prerequisite. For many cell …