The ability to respond to variations in nutritional status depends on regulatory systems that
monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient …

Reduced dietary protein intake induces adaptive physiological changes in macronutrient
preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that …

Summary Fibroblast growth factor 21 (FGF21), an endocrine signal robustly increased by
protein restriction independently of an animal's energy status, exerts profound effects on …

Whereas carbohydrates and lipids are stored as glycogen and fat, there is no analogous
inert storage form of protein. Therefore, continuous adjustments in feeding behavior are …

Fibroblast growth factor 21 (FGF21) is a stress hormone that is released from the liver in
response to nutritional and metabolic challenges. In addition to its well-described effects on …

Restriction of dietary protein intake increases food intake and energy expenditure, reduces
growth, and alters amino acid, lipid, and glucose metabolism. While these responses …

Biological mechanisms to promote dietary balance remain unclear. Fibroblast growth factor
21 (FGF21) has been suggested to contribute to such potential regulation considering that …

Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to
the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 …

Summary Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the
liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in …

Summary Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated
by protein restriction. Although FGF21 is robustly elevated in low-protein environments …