receptor antisense oligonucleotide administration into the cerebral ventricles reduced
baseline sympathetic nerve activity in rats with CHF while having no effect in normal rats. 36 …

Previous studies showed that the cardiac sympathetic afferent reflex (CSAR) is enhanced in
dogs and rats with chronic heart failure (CHF) and that central ANG II type 1 receptors …

Sympatho‐excitation is a hallmark of the chronic heart failure (CHF) state. It has long been
assumed that this sympatho‐excitation is mediated by a reduction in sensory input from …

It has been established that the baroreflex is markedly decreased in chronic heart failure
(CHF). Our recent study has indicated that activation of the cardiac sympathetic afferent …

Enhanced sympathetic outflow is seen in both patients with congestive heart failure and
animals with experimental heart failure. In a previous study, we demonstrated that the …

Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the
sympathetic nervous system in heart failure (HF). We reported recently that Ang II stimulates …

Chronic heart failure (HF) is characterized by increased sympathetic drive. Enhanced
angiotensin II (ANG II) activity may contribute to the increased sympathoexcitation under HF …

Blockade of the angiotensin II (ANG II) type 1 receptor (AT1) has been shown to restore
baroreflex sensitivity in rats and rabbits with experimental chronic heart failure (CHF) …

To provide evidence for the role of angiotensin II locally produced in the brain in the
development of sympathetic hyperactivity and heart failure after myocardial infarction (MI) …

Because the renin-angiotensin system is activated in heart failure, we hypothesized that
angiotensin II (ANG II) plays a role in altering baroreflex sensitivity in the setting of heart …