Novel mechanisms of sympathetic regulation in chronic heart failure
IH Zucker - Hypertension, 2006 - Am Heart Assoc
receptor antisense oligonucleotide administration into the cerebral ventricles reduced
baseline sympathetic nerve activity in rats with CHF while having no effect in normal rats. 36 …
baseline sympathetic nerve activity in rats with CHF while having no effect in normal rats. 36 …
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure
GQ Zhu, L Gao, Y Li, KP Patel… - American Journal of …, 2004 - journals.physiology.org
Previous studies showed that the cardiac sympathetic afferent reflex (CSAR) is enhanced in
dogs and rats with chronic heart failure (CHF) and that central ANG II type 1 receptors …
dogs and rats with chronic heart failure (CHF) and that central ANG II type 1 receptors …
The regulation of sympathetic outflow in heart failure: the roles of angiotensin II, nitric oxide, and exercise training
IH Zucker, W Wang, RU Pliquett… - Annals of the New …, 2001 - Wiley Online Library
Sympatho‐excitation is a hallmark of the chronic heart failure (CHF) state. It has long been
assumed that this sympatho‐excitation is mediated by a reduction in sensory input from …
assumed that this sympatho‐excitation is mediated by a reduction in sensory input from …
Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure
It has been established that the baroreflex is markedly decreased in chronic heart failure
(CHF). Our recent study has indicated that activation of the cardiac sympathetic afferent …
(CHF). Our recent study has indicated that activation of the cardiac sympathetic afferent …
Angiotensin II enhances baroreflex control of sympathetic outflow in heart failure
H Murakami, JL Liu, IH Zucker - Hypertension, 1997 - Am Heart Assoc
Enhanced sympathetic outflow is seen in both patients with congestive heart failure and
animals with experimental heart failure. In a previous study, we demonstrated that the …
animals with experimental heart failure. In a previous study, we demonstrated that the …
Angiotensin II–triggered p44/42 mitogen-activated protein kinase mediates sympathetic excitation in heart failure rats
Angiotensin II (Ang II), acting via angiotensin type 1 receptors in the brain, activates the
sympathetic nervous system in heart failure (HF). We reported recently that Ang II stimulates …
sympathetic nervous system in heart failure (HF). We reported recently that Ang II stimulates …
Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure
H Zheng, YF Li, W Wang… - American Journal of …, 2009 - journals.physiology.org
Chronic heart failure (HF) is characterized by increased sympathetic drive. Enhanced
angiotensin II (ANG II) activity may contribute to the increased sympathoexcitation under HF …
angiotensin II (ANG II) activity may contribute to the increased sympathoexcitation under HF …
ANG II and baroreflex function in rabbits with CHF and lesions of the area postrema
JL Liu, H Murakami, M Sanderford… - American Journal …, 1999 - journals.physiology.org
Blockade of the angiotensin II (ANG II) type 1 receptor (AT1) has been shown to restore
baroreflex sensitivity in rats and rabbits with experimental chronic heart failure (CHF) …
baroreflex sensitivity in rats and rabbits with experimental chronic heart failure (CHF) …
Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen
H Wang, BS Huang, D Ganten, FHH Leenen - Circulation research, 2004 - Am Heart Assoc
To provide evidence for the role of angiotensin II locally produced in the brain in the
development of sympathetic hyperactivity and heart failure after myocardial infarction (MI) …
development of sympathetic hyperactivity and heart failure after myocardial infarction (MI) …
Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure
H Murakami, JL Liu, IH Zucker - American Journal of …, 1996 - journals.physiology.org
Because the renin-angiotensin system is activated in heart failure, we hypothesized that
angiotensin II (ANG II) plays a role in altering baroreflex sensitivity in the setting of heart …
angiotensin II (ANG II) plays a role in altering baroreflex sensitivity in the setting of heart …
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