Ocular indicators of Alzheimer's: exploring disease in the retina

NJ Hart, Y Koronyo, KL Black… - Acta neuropathologica, 2016 - Springer
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …

Alzheimer's retinopathy: seeing disease in the eyes

N Mirzaei, H Shi, M Oviatt, J Doustar… - Frontiers in …, 2020 - frontiersin.org
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Visual and ocular manifestations of Alzheimer's disease and their use as biomarkers for diagnosis and progression

FZ Javaid, J Brenton, L Guo, MF Cordeiro - Frontiers in neurology, 2016 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia affecting the growing aging
population today, with prevalence expected to rise over the next 35 years. Clinically, patients …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Amyloid beta immunoreactivity in the retinal ganglion cell layer of the Alzheimer's eye

S Lee, K Jiang, B McIlmoyle, E To, Q Xu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60–70% of
all dementias. AD is often under-diagnosed and recognized only at a later, more advanced …

Reflections on the utility of the retina as a biomarker for Alzheimer's disease: a literature review

J Ngolab, P Honma, RA Rissman - Neurology and therapy, 2019 - Springer
As a part of the central nervous system, the retina may reflect both physiologic processes
and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put …

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas

J den Haan, THJ Morrema, FD Verbraak… - Acta neuropathologica …, 2018 - Springer
In-vivo labeling of retinal amyloid-beta (Aβ) and tau has potential as non-invasive biomarker
for Alzheimer's disease (AD). However, literature on the presence of Aβ and phosphorylated …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Visual system manifestations of Alzheimer's disease

Y Kusne, AB Wolf, K Townley, M Conway… - Acta …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is an increasingly common disease with massive personal and
economic costs. While it has long been known that AD impacts the visual system, there has …