The discovery of new bioactive compounds from marine natural sources is very important in
pharmacological research. Here we developed a Wnt responsive luciferase reporter assay …

Reduced-gliotoxin is a small molecule derived from the secondary metabolites of marine
fungi; compared to other gliotoxin analogues, it exhibits potent anticancer effects. However …

Acquired drug resistance constitutes an enormous hurdle in cancer treatment, and the
search for effective compounds against resistant cancer is still advancing. Marine organisms …

Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses
various biological activities including anticancer activity. However, the mechanism …

Gliotoxin has been recognized as an immunosuppressive agent for a long time. Recently, it
was reported to have antitumor properties. However, the mechanisms by which it inhibits …

Ginkgolide C (GGC), isolated from Ginkbiloba, has been reported to display various
pharmacological actions, although, anti‐cancer effect of GGC has been poorly understood …

It has been well established that radiation-induced gastrointestinal injury is manifested
through loss of intestinal crypt stem cells and disruption of the mucosal layers, resulting in …

An aberrant accumulation of β-catenin in intestinal epithelial cells is relevant to the
development and progression of colon cancer and is thus a potential target for the …

Dysregulated Wnt signaling is associated with malignant oncogenic transformation,
especially in colon cancer. Recently, numerous drugs have been developed based on …

The purpose of the study was to elucidate the mechanism underlying the enhancement of
radiosensitivity to 60Co γ‐irradiation in human hepatoma cell line HepG2 pretreated with …