Ovarian deficiency, including premature ovarian insufficiency (POI) and diminished ovarian
reserve (DOR), represents one of the main causes of female infertility. POI is a genetically …

Context Primary ovarian insufficiency (POI) affects 1% of women under 40 years of age. POI
is idiopathic in more than 70% of cases. Though many candidate genes have been …

Background The loss of ovarian function in women, referred to as premature ovarian
insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically …

Primary ovarian insufficiency (POI) is characterized by amenorrhea, increased follicle-
stimulating hormone (FSH) levels, and hypoestrogenism, leading to infertility before the age …

Primary ovarian insufficiency (POI), also known as premature ovarian failure or premature
menopause, is defined as cessation of menstruation before the expected age of …

Premature ovarian failure (POF) is a common cause of infertility in women, characterized by
amenorrhea, hypoestrogenism, and elevated gonadotropin levels in women under the age …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

Premature ovarian insufficiency (POI) is highly heterogeneous in genetic etiology. Yet
identifying causative genes has been challenging with candidate gene approaches. Recent …

Background To dissect the genetic alteration in two sisters with premature ovarian
insufficiency (POI) from a consanguineous family. Methods Whole-exome sequencing …

Several causes for primary ovarian insufficiency (POI) have been described, including
iatrogenic and environmental factor, viral infections, chronic disease as well as genetic …