Genetic information is encoded by the four bases adenine (A), guanine (G), cytosine (C),
and thymine (T). Base pairing through hydrogen bonding between the cognate pairs AT and …

The four canonical bases that make up genomic DNA are subject to a variety of chemical
modifications in living systems. Recent years have witnessed the discovery of various new …

While some DNA base modifications such as 5-methylcytosine have been known and
studied for decades, recent discoveries of a number of other modified bases have stimulated …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

Research in nucleic acids has made major advances in the past decade in multiple fields of
science and technology. Here we discuss some of the most important findings in DNA and …

Chemically modified bases exist naturally in genomic DNA. Research into these bases has
been invigorated by the discovery of several modified bases in the mammalian genome, in …

Several years ago, an Account from this laboratory emphasized how chemically synthesized
deoxyoligonucleotides could be used to deduce some of the key mechanisms whereby …

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular
scaffold, arranging smaller organic structures into predesigned geometries. Herein are …

Highlights•Modified nucleotides stabilize and increase the potential functions of DNA and
RNA.•Modified nucleotides allow DNA and RNA to adopt protein-like structures.• …

The ability of various nucleoside triphosphate analogues of deoxyguanosine and
deoxycytidine with 7‐deazadeoxyadenosine (A1) and 5‐chlorodeoxyuridine (T1) to serve as …