Bone biomineralization is a complex process in which type I collagen and associated non-
collagenous proteins (NCPs), including glycoproteins and proteoglycans, interact closely …

The impact of genetics has dramatically affected our understanding of the functions of non-
collagenous proteins. Specifically, mutations and knockouts have defined their cellular …

Mineralization of vertebrate tissues such as bone, dentin, cementum, and calcifying tendon
involves type I collagen, which has been proposed as a template for calcium and phosphate …

Purpose of review: Mineralization of the extracellular matrix is crucial for the development
and maintenance of healthy bones and teeth, but also contributes to the pathologic …

Among the vertebrate species, collagen is the most abundant protein and is associated with
mineralization of their skeleton and dentition in all tissues except enamel. In such tissues …

Improved technologies have led to the isolation of a large number of noncollagenous matrix
proteins from the mineralized connective tissues. These proteins have been postulated to …

OBJECTIVES: Noncollagenous proteins (NCPs) play distinct and overlap roles in controlling
the mineralization of bone, while the relationship between the NCPs and the mineral phase …

A full-length cDNA clone encoding osteocalcin from the bullfrog, Rana catesbeiana (bone
Gla-protein, BGP) has been isolated, and the complete coding sequence for the 100-amino …

A calcium ion precipitable, trypsin-generated proteoglycan fragment has been isolated from
the demineralized, EDTA-insoluble matrices of bone. The demineralized matrix was …

The skeleton of mammals and other vertebrates consists of a mineral phase (an analog of
the geologic mineral hydroxyapatite) and an organic phase (principally collagen). The …