[HTML][HTML] ZEB1: catalyst of immune escape during tumor metastasis

J Lu, F Fei, C Wu, J Mei, J Xu, P Lu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

[HTML][HTML] Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

[HTML][HTML] Post-translational modification of ZEB family members in cancer progression

MK Park, H Lee, CH Lee - International Journal of Molecular Sciences, 2022 - mdpi.com
Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play
essential roles in physiological and pathological processes. In addition, PTM functions in …

The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

[HTML][HTML] ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance

S Drápela, J Bouchal, MK Jolly, Z Culig… - Frontiers in molecular …, 2020 - frontiersin.org
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

Effect of downregulation of ZEB1 on vimentin expression, tumour migration and tumourigenicity of melanoma B16F10 cells and CSCs

J Dou, X He, Y Liu, Y Wang, F Zhao… - Cell biology …, 2014 - Wiley Online Library
Zinc‐finger E‐box binding homeobox 1 (ZEB1) is a master regulator of epithelial‐
mesenchymal transition (EMT) and has been implicated in primary epithelial cancer …

[HTML][HTML] ZEB1 transcription factor promotes immune escape in melanoma

M Plaschka, V Benboubker, M Grimont… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The efficacy of immunotherapies in metastatic melanoma depends on a robust
T cell infiltration. Oncogenic alterations of tumor cells have been associated to T cell …

Role of ZEB family members in proliferation, metastasis, and chemoresistance of prostate cancer cells: revealing signaling networks

A Zarrabi, F Hashemi, F Hashemi… - Current cancer drug …, 2021 - ingentaconnect.com
Prostate cancer (PCa) is one of the leading causes of death worldwide. A variety of
strategies, including surgery, chemotherapy, radiotherapy, and immunotherapy, are applied …