In vivo fate of cowpea mosaic virus in situ vaccine: biodistribution and clearance

JF Affonso de Oliveira, SK Chan, AO Omole… - ACS …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) is a nucleoprotein nanoparticle that functions as a highly
potent immunomodulator when administered intratumorally and is used as an in situ …

[HTML][HTML] In situ vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy

PL Chariou, V Beiss, Y Ma, NF Steinmetz - Materials advances, 2021 - pubs.rsc.org
Cowpea mosaic virus (CPMV) is currently in the development pipeline for multiple
biomedical applications, including cancer immunotherapy. In particular the application of …

Antibody Response against Cowpea Mosaic Viral Nanoparticles Improves In Situ Vaccine Efficacy in Ovarian Cancer

S Shukla, C Wang, V Beiss, NF Steinmetz - ACS nano, 2020 - ACS Publications
Cancer immunotherapies are designed to facilitate recognition and elimination of
transformed cells by the immune system. We have established the immunotherapeutic …

Inactivated cowpea mosaic virus for in situ vaccination: differential efficacy of formalin vs UV-inactivated formulations

E Jung, C Mao, M Bhatia, EC Koellhoffer… - Molecular …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) has been developed as a promising nanoplatform technology
for cancer immunotherapy; when applied as in situ vaccine, CPMV exhibits potent, systemic …

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

PH Lizotte, AM Wen, MR Sheen, J Fields… - Nature …, 2016 - nature.com
Nanotechnology has tremendous potential to contribute to cancer immunotherapy. The 'in
situ vaccination'immunotherapy strategy directly manipulates identified tumours to overcome …

Cowpea mosaic virus nanoparticles and empty virus-like particles show distinct but overlapping immunostimulatory properties

C Wang, V Beiss, NF Steinmetz - Journal of virology, 2019 - Am Soc Microbiol
Cowpea mosaic virus (CPMV) is a plant virus that has been developed for multiple
biomedical and nanotechnology applications, including immunotherapy. Two key platforms …

In situ vaccination of tumors using plant viral nanoparticles

AA Murray, MR Sheen, FA Veliz, SN Fiering… - Pharmaceutical …, 2019 - Springer
Viral nanoparticles are self-assembling units that are being developed and applied for a
variety of applications. While most clinical uses involve animal viruses, a plant-derived virus …

Cowpea mosaic virus and natural killer cell agonism for in situ cancer vaccination

EC Koellhoffer, NF Steinmetz - Nano letters, 2022 - ACS Publications
We have previously shown the plant virus Cowpea mosaic virus (CPMV) to be an efficacious
in situ cancer vaccine, providing elimination of tumors and tumor-specific immune memory …

Inactivated cowpea mosaic virus in combination with OX40 agonist primes potent antitumor immunity in a bilateral melanoma mouse model

EC Koellhoffer, C Mao, V Beiss, L Wang… - Molecular …, 2022 - ACS Publications
Viral immunotherapies are being recognized in cancer treatment, with several currently
approved or undergoing clinical testing. While contemporary approaches have focused on …

Cowpea mosaic virus outperforms other members of the Secoviridae as in situ vaccine for cancer immunotherapy

V Beiss, C Mao, SN Fiering… - Molecular …, 2022 - ACS Publications
In situ vaccination for cancer immunotherapy uses intratumoral administration of small
molecules, proteins, nanoparticles, or viruses that activate pathogen recognition receptors …