Recognition of methamphetamine and other amines by trace amine receptor TAAR1
Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
Ligand recognition and G-protein coupling of trace amine receptor TAAR1
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …
essential roles in neurological and metabolic homeostasis. They recognize diverse …
Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine
EA Reese, JR Bunzow, S Arttamangkul… - … of Pharmacology and …, 2007 - ASPET
The synthetic amines methamphetamine (METH), amphetamine (AMPH), and their
metabolite para-hydroxyamphetamine (POHA) are chemically and structurally related to the …
metabolite para-hydroxyamphetamine (POHA) are chemically and structurally related to the …
In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1
LD Simmler, D Buchy, S Chaboz, MC Hoener… - … of Pharmacology and …, 2016 - ASPET
Trace amine-associated receptor 1 (TAAR1) has been implicated in the behavioral effects of
amphetamine-type stimulant drugs in rodents. TAAR1 has also been suggested as a target …
amphetamine-type stimulant drugs in rodents. TAAR1 has also been suggested as a target …
Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine
FG Revel, CA Meyer, A Bradaia, K Jeanneau… - …, 2012 - nature.com
Trace amines (TAs) such as β-phenylethylamine, p-tyramine, or tryptamine are biogenic
amines found in the brain at low concentrations that have been implicated in various …
amines found in the brain at low concentrations that have been implicated in various …
TAAR1 as an emerging target for the treatment of psychiatric disorders
Trace amines, a group of amines expressed at the nanomolar level in the mammalian brain,
can modulate monoamine transmission. The discovery of and the functional research on the …
can modulate monoamine transmission. The discovery of and the functional research on the …
Trace amine-associated receptors as emerging therapeutic targets
TD Sotnikova, MG Caron, RR Gainetdinov - Molecular Pharmacology, 2009 - ASPET
Endogenous trace amines (TAs) of unknown biological function are structurally related to
classic monoaminergic neurotransmitters and found at low concentrations in the mammalian …
classic monoaminergic neurotransmitters and found at low concentrations in the mammalian …
Trace amine-associated receptor 1—Family archetype or iconoclast?
DK Grandy - Pharmacology & therapeutics, 2007 - Elsevier
Interest has recently been rekindled in receptors that are activated by low molecular weight,
noncatecholic, biogenic amines that are typically found as trace constituents of various …
noncatecholic, biogenic amines that are typically found as trace constituents of various …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
Trace amine-associated receptor 1 as a monoaminergic modulator in brain
Z Xie, GM Miller - Biochemical pharmacology, 2009 - Elsevier
Brain monoaminergic systems play critical roles in mood, cognition, emotion, reward,
learning and attention, and aberrance in brain monoaminergic activity is associated with a …
learning and attention, and aberrance in brain monoaminergic activity is associated with a …