The recently ascertained network and dynamic organization of the mitochondrion, as well as
the demonstration of energy proteins and metabolites subcompartmentalization, have led to …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Beyond their fundamental role in energy metabolism, mitochondria perform a great variety of
other important cellular functions. However, the interplay among these various roles of …

Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Mitochondria form a dynamic network, and it remains unclear how the alternate
configurations interact with bioenergetics properties. The metabolic signals that link …

Mitochondria are the powerhouses of the eukaryotic cell. After billions of years of evolution,
mitochondria have adaptively integrated into the symbiont. Such integration is not only …

Dynamic change in mitochondrial shape is a cellular process mediated mainly by fission
and fusion of mitochondria. Studies have shown that mitochondrial fission and fusion are …

The dynamic and fluid nature of mitochondria allows for modifications in mitochondrial
shape, connectivity and cristae architecture. The precise balance of mitochondrial dynamics …

To maintain homeostasis, every cell must constantly monitor its energy level and
appropriately adjust energy, in the form of ATP, production rates based on metabolic …