Anticancer properties of bromelain: State-of-the-art and recent trends

R Pezzani, M Jimenez-Garcia, X Capo… - Frontiers in …, 2023 - frontiersin.org
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …

Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives

K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

[PDF][PDF] A review on potential properties and therapeutic applications of bromelain

B Kwatra - World J. Pharm. Pharm. Sci, 2019 - researchgate.net
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a
mixture of different thiol endopeptidases and other components. Bromelain is a mixture of …

Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)

A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

[HTML][HTML] Bromelain: a potent phytomedicine

P Agrawal, P Nikhade, A Patel, N Mankar, S Sedani - Cureus, 2022 - ncbi.nlm.nih.gov
The commercially available protein-digesting enzyme bromelain is derived from the
pineapple fruit or stem. Bromelain from fruit and stems are produced in different ways and …

Properties and therapeutic application of bromelain: a review

R Pavan, S Jain, Shraddha… - Biotechnology research …, 2012 - Wiley Online Library
Bromelain belongs to a group of protein digesting enzymes obtained commercially from the
fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and …

Recent advances and insights into bromelain processing, pharmacokinetics and therapeutic uses

A Colletti, S Li, M Marengo, S Adinolfi, G Cravotto - Applied Sciences, 2021 - mdpi.com
Bromelain is a mixture of proteolytic enzymes that is extracted primarily from pineapples. It is
present in almost all the aerial parts of the plant—the peels, leaves, stems and fruit …

Bromelain a potential bioactive compound: a comprehensive overview from a pharmacological perspective

AJ Chakraborty, S Mitra, TE Tallei, AM Tareq, F Nainu… - Life, 2021 - mdpi.com
Bromelain is an effective chemoresponsive proteolytic enzyme derived from pineapple
stems. It contains several thiol endopeptidases and is extracted and purified via several …

Bromelain: biochemistry, pharmacology and medical use

HR Maurer - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Bromelain is a crude extract from the pineapple that contains, among other components,
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …

Bromelain-induced apoptosis in GI-101A breast cancer cells

S Dhandayuthapani, HD Perez, A Paroulek… - Journal of medicinal …, 2012 - liebertpub.com
Bromelain is a proteolytic enzyme extracted from the stems and the immature fruits of
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …