Peripheral nerve injury induces cortical remapping that can lead to sensory complications.
There is evidence that inhibitory interneurons play a role in this process, but the exact …

Inhibitory interneurons are an important component of dorsal horn circuitry where they serve
to modulate spinal nociception. There is now considerable evidence indicating that reduced …

Diverse interneuron subtypes determine how cortical circuits process sensory information
depending on their connectivity. Sensory deprivation experiments are ideally suited to …

Reflex abnormalities mediated by proprioceptive sensory neurons after peripheral nerve
injury (PNI) can limit functional improvement, leaving patients with disability that affects their …

Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with
autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not …

Following a spinal cord injury (SCI), secondary damage mechanisms are triggered that
cause inflammation and cell death. A key component of this secondary damage is a …

Primary sensory neurons are generally considered the only source of dorsal horn calcitonin
gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages …

In this study we explore if loss of GABAergic inhibitory interneurons in the superficial dorsal
horn of the spinal cord contributes to reduced GABAergic tone and neuropathic pain …

Dysfunction of the spinal GABAergic system has been implicated in pain syndromes
following spinal cord injury (SCI). Since lamina I is involved in nociceptive and thermal …

Mice with transgenic insertion of code for enhanced green fluorescent protein (EGFP) at the
locus for glutamic acid decarboxylase 67 (GAD67), one of two key enzymes for the synthesis …