Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson's Disease

B da Silva Oliveira, EC de Brito Toscano, LKS Abreu… - Neuroscience, 2024 - Elsevier
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's
disease (PD). Inflammatory response has been associated with symptoms and subtypes of …

Nigrostriatal inflammation is associated with nonmotor symptoms in an experimental model of prodromal Parkinson's disease

BS Oliveira, ECB Toscano, LKS Abreu, HB Fernandes… - 2023 - researchsquare.com
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's
disease (PD). However, it is unclear whether the immune changes are involved in the initial …

Effect of NAC treatment and physical activity on neuroinflammation in subchronic Parkinsonism; is physical activity essential?

AL Gil-Martínez, L Cuenca, C Sánchez… - Journal of …, 2018 - Springer
Background Neuroprotective strategies are becoming relevant to slow down dopaminergic
cell death and inflammatory processes related to the progressive neurodegeneration in …

[HTML][HTML] Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series

V Joers, G Masilamoni, D Kempf, AR Weiss… - Neurobiology of …, 2020 - Elsevier
Inflammation has been linked to the development of nonmotor symptoms in Parkinson's
disease (PD), which greatly impact patients' quality of life and can often precede motor …

Neuroinflammation as a potential mechanism underlying parkinsons disease

C Cebrián, D Sulzer - Parkinson's Disease, 2017 - Elsevier
The motor symptoms of Parkinsons disease (PD) are due to the progressive degeneration of
dopaminergic neurons in the substantia nigra. Multiple neuroinflammatory processes are …

An inflammatory pathomechanism for Parkinson's disease?

C Wersinger, A Sidhu - Current medicinal chemistry, 2006 - ingentaconnect.com
Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder characterized
by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), striatal …

Double triggers, nasal induction of a Parkinson's disease mouse model

G Song, G Xi, Y Li, Y Zhao, C Qi, L Song, B Xiao… - Neuroscience …, 2020 - Elsevier
Animal models of Parkinson's disease (PD), a chronic and progressive neurodegenerative
disease of the central nervous system (CNS), play a key role in investigating the …

Intranigral LPS administration produces dopamine, glutathione but not behavioral impairment in comparison to MPTP and 6-OHDA neurotoxin models of Parkinson's …

D Ariza, MMS Lima, CG Moreira, PA Dombrowski… - Neurochemical …, 2010 - Springer
The current investigation compared intranigral lipopolysaccharide (LPS), 1-methyl-4-phenyl-
1, 2, 3, 6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) administrations, in …

Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in parkinson′ s disease …

A Machado, AJ Herrera, JL Venero… - Parkinson's …, 2011 - Wiley Online Library
Inflammatory processes described in Parkinson's disease (PD) and its animal models
appear to be important in the progression of the pathogenesis, or even a triggering factor …

Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 …

A Vroon, B Drukarch, JGJM Bol, P Cras… - Experimental …, 2007 - Elsevier
Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The
present study questioned whether this neuroinflammatory response differs between the …