Dermal immunization using antigen-coated microneedle arrays is a promising vaccination
strategy. However, reduction of microneedle sharpness and the available surface area for …

The aim of this work was to study the applicability of antigen-coated pH-sensitive
microneedle arrays for effective vaccination strategies. Therefore, a model antigen …

Transcutaneous immunization (TCI) is limited by poor permeation of macromolecules across
the skin. Microneedle arrays form transient conduits and enhance the transport of vaccine …

Purpose The purpose of this study was to gain insight into the delivery and immunogenicity
of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT) formulations applied …

Reducing the dosage required for vaccination is highly desirable, particularly in cases of
epidemic emergencies. This study evaluated the potential of a chitosan microneedle (MN) …

The aim of this work was to coat pH-sensitive microneedle arrays with inactivated polio
vaccine (IPV) particles and N-trimethyl chitosan chloride (TMC) via electrostatic interactions …

This study focused on the development of novel coating formulations for stainless steel
microneedles against influenza A virus. With in vitro studies, various viscosity enhancers …

Antigen-loaded dissolving microneedle array (dMNA) patches were investigated as novel
systems for vaccine delivery into the skin, where immuno-competent dendritic cells are …

This study introduces a microneedle transdermal delivery system, composed of embeddable
chitosan microneedles and a poly (l-lactide-co-d, l-lactide)(PLA) supporting array, for …

Enhancing the immune response to vaccines and minimizing the need for repeated
inoculations remain a challenge in clinical vaccination. This study developed a composite …