A systems understanding of nuclear organization and events is critical for determining how
cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases …

Members of the Swi/Snf family of chromatin-remodeling complexes play critical roles in
transcriptional control. Recent studies have made significant advances in our understanding …

Chromatin-remodeling enzymes play essential roles in many biological processes, including
gene expression, DNA replication and repair, and cell division. Although one such complex …

Abstract Mammalian SWI/SNF (BAF) chromatin remodeling complexes play critical roles in
maintaining chromatin architecture and gene expression. Genomic sequencing efforts over …

Summary The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to
humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or …

The SWI/SNF complex is a highly conserved multisubunit assembly that facilitates the
function of gene-specific transcriptional regulatory proteins by antagonizing chromatin …

There is increasing evidence that alterations in chromatin remodeling play a significant role
in human disease. The SWI/SNF chromatin remodeling complex family mobilizes …

By regulating the structure of chromatin, ATP-dependent chromatin remodeling complexes
(remodelers) perform critical functions in the maintenance, transmission and expression of …

Chromatin presents a significant obstacle to transcription, but two means of overcoming its
repressive effects, histone acetylation and the activities of the Swi–Snf complex, have been …

Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …