[HTML][HTML] Primary endothelial cell–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia
R Bartoszewski, A Moszyńska, M Serocki… - The FASEB …, 2019 - ncbi.nlm.nih.gov
During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
[HTML][HTML] Hypoxia-inducible factor (HIF)-3a2 serves as an endothelial cell fate executor during chronic hypoxia
M Jaskiewicz, A Moszynska, M Serocki… - EXCLI …, 2022 - ncbi.nlm.nih.gov
The adaptive response to hypoxia involves the transcriptional induction of three transcription
factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which …
factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which …
Cell-specific and hypoxia-dependent regulation of human HIF-3α: inhibition of the expression of HIF target genes in vascular cells
A Augstein, DM Poitz, RC Braun-Dullaeus… - Cellular and molecular …, 2011 - Springer
Hypoxia-inducible factors (HIF) are transcription factors responding to reduced oxygen
levels and are of utmost importance for regulation of a widespread of cellular processes, eg …
levels and are of utmost importance for regulation of a widespread of cellular processes, eg …
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
M Jaśkiewicz, A Moszyńska, J Króliczewski… - Cellular & molecular …, 2022 - Springer
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …
miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF) 1A and HIF3A expression in human endothelial cells
Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to
adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …
adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
S Rey, GL Semenza - Cardiovascular research, 2010 - academic.oup.com
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu, LY Wang, LA Chodosh, B Keith… - Molecular and cellular …, 2003 - Taylor & Francis
Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor
(HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator …
(HIF), a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator …
HIF-1 versus HIF-2—is one more important than the other?
A Loboda, A Jozkowicz, J Dulak - Vascular pharmacology, 2012 - Elsevier
Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …
maintain physiological oxygen tension for a particular tissue. It is well-established that when …
[HTML][HTML] The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop
Abstract Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric α/β transcription factors that
regulate cellular responses to low oxygen. HIF-1 is induced first, whereas HIF-2 is …
regulate cellular responses to low oxygen. HIF-1 is induced first, whereas HIF-2 is …
Passing the baton: the HIF switch
MY Koh, G Powis - Trends in biochemical sciences, 2012 - cell.com
Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …