Objective A novel approach to regulate obesity-associated adipose inflammation may be
through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs …

Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that
regulate this inflammatory response and link adipose inflammation to systemic metabolic …

Chronic inflammation in obese adipose tissue is linked to endoplasmic reticulum (ER) stress
and systemic insulin resistance. Targeted deletion of the murine fatty acid binding protein …

Fatty acid (FA) metabolism is a series of processes that provide structural substances,
signalling molecules and energy. Ample evidence has shown that FA uptake is mediated by …

Adipose-tissue-resident macrophages (ATMs) maintain metabolic homeostasis but also
contribute to obesity-induced adipose tissue inflammation and metabolic dysfunction …

Macrophages are important cells that need to be controlled at the site of inflammation.
Several factors are involved in chronic inflammation and its timely resolution. Free fatty acids …

Aims/hypothesis Recent studies have identified intracellular metabolism as a fundamental
determinant of macrophage function. In obesity, proinflammatory macrophages accumulate …

Tissue-resident macrophages are the most abundant immune cell population in healthy
adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and …

It is becoming increasingly apparent that mutual interactions between adipocytes and
immune cells are key to the integrated control of adipose tissue inflammation and lipid …

Fatty acid oxidation in macrophages has been suggested to play a causative role in high-fat
diet-induced metabolic dysfunction, particularly in the etiology of adipose-driven insulin …