Loss of ERβ increases primordial follicle growth activation (PFGA), leading to premature
ovarian follicle reserve depletion. We determined the expression and gene regulatory …

Gonadotropins are essential for regulating ovarian development, steroidogenesis, and
gametogenesis. While follicle stimulating hormone (FSH) promotes the development of …

Over the entire reproductive lifespan in mammals, a fixed number of primordial follicles
serve as the source of mature oocytes. Uncontrolled and excessive activation of primordial …

Both estrogen receptor (ER) α and β are expressed within the ovary and lack of either of
these receptors affects ovarian function. In this study, the role of ERα and ERβ in …

Increased activation of ovarian primordial follicles in Erβ knockout (ErβKO) rats becomes
evident as early as postnatal day 8.5. To identify the ERβ-regulated genes that may control …

Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

The formation of primordial follicles involves the interaction between the oocytes and
surrounding somatic cells, which differentiate into granulosa cells. Estradiol-17ß (E) …

Follicle development beyond the preantral stage is dependent on gonadotropins. FSH
signaling is crucial for the advancement of preantral follicles to the antral stage, and LH …

Background Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and
ovulation, yet its exact mechanism of action is mainly uncharacterized. Results We here …

Gonadotropin-stimulated estrogen receptor-β (ERβ)-null preovulatory follicles exhibit
submaximal estradiol production, insufficient acquisition of LH receptor, and attenuated …