Metabolic syndrome and amyloid accumulation in the aging brain

G Gomez, LL Beason-Held, M Bilgel… - Journal of …, 2018 - content.iospress.com
Background: Recent studies show links between metabolic syndrome and Alzheimer's
disease (AD) neuropathology. Understanding the link between vascular-related health …

Longitudinal effects of metabolic syndrome on Alzheimer and vascular related brain pathology

F Lin, RY Lo, D Cole, S Ducharme, DG Chen… - Dementia and geriatric …, 2014 - karger.com
Abstract Background/Aims: This study examines the longitudinal effect of metabolic
syndrome (MetS) on brain-aging indices among cognitively normal (CN) and amnestic mild …

Metabolic syndrome and its components in relation to in vivo brain amyloid and neurodegeneration in late middle age

P Palta, B Rippon, M Tahmi, G Sherwood, L Soto… - Neurobiology of …, 2021 - Elsevier
Metabolic syndrome (MetS) is associated with dementia, but it is unclear whether MetS is
related to Alzheimer's disease (AD). We investigated the association of MetS with brain …

Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression

K Nho, A Kueider-Paisley, M Arnold… - Brain …, 2021 - academic.oup.com
Metabolomics in the Alzheimer's Disease Neuroimaging Initiative cohort provides a powerful
tool for mapping biochemical changes in Alzheimer's disease, and a unique opportunity to …

Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York …

MJ Walters, J Sterling, C Quinn, C Ganzer, RS Osorio… - BMJ open, 2018 - bmjopen.bmj.com
Objective To investigate the associations between lifestyle and vascular risk factors and
changes in Alzheimer's disease (AD) biomarkers (beta-amyloid load via 11C-PiB PET …

Associations between serum cholesterol levels and cerebral amyloidosis

B Reed, S Villeneuve, W Mack, C DeCarli… - JAMA …, 2014 - jamanetwork.com
Importance Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event
in Alzheimer disease (AD), factors associated with increased deposition are of great interest …

Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis?

HJ Milionis, M Florentin, S Giannopoulos - CNS spectrums, 2008 - cambridge.org
Current evidence from epidemiological, neuroimaging, pathological, pharmacotherapeutic,
and clinical studies indicate an association of Alzheimer's disease with risk factors of …

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative

JB Toledo, E Toledo, MW Weiner, CR Jack Jr… - Alzheimer's & …, 2012 - Elsevier
BACKGROUND: There is epidemiological evidence that cardiovascular risk factors (CVRF)
also are risk factors for Alzheimer's disease, but there is limited information on this from …

Association of hypometabolism and amyloid levels in aging, normal subjects

VJ Lowe, SD Weigand, ML Senjem, P Vemuri… - Neurology, 2014 - AAN Enterprises
Objective: We evaluated the relationship of amyloid, seen on Pittsburgh compound B (PiB)-
PET, and metabolism, seen on [18F]-fluorodeoxyglucose (FDG)-PET, in normal subjects to …

Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer's disease

JA Pillai, J Bena, L Bekris, N Kodur, T Kasumov… - Alzheimer's research & …, 2023 - Springer
Background The relationship between biomarkers of metabolic syndrome and insulin
resistance, plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio, on the rate of cognitive …