The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Improvements in health care have increased human life expectancy in recent decades, and
the elderly population is thus increasing in most developed countries. Unfortunately this still …

Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and
longevity in model organisms and humans, without the challenges of maintaining a CR diet …

When considering all possible aging interventions evaluated to date, it is clear that calorie
restriction (CR) remains the most robust. Studies in numerous species have demonstrated …

Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …

Nutrient depletion, which is one of the physiological triggers of autophagy, results in the
depletion of intracellular acetyl coenzyme A (AcCoA) coupled to the deacetylation of cellular …

Aging is a biological process determined by multiple cellular mechanisms, such as genomic
instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient …

Strong consensus exists regarding the most robust environmental intervention for
attenuating aging processes and increasing healthspan and lifespan: calorie restriction …

Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being
tested in nonhuman primates. One way to apply these findings to human health is to identify …