The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …

Transcription factors of the interferon regulatory factor (IRF) family commands the entire type
I interferon (IFN) system from induction of IFNs to diverse IFN responses, thereby providing a …

Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense
and are essential for mobilizing immune responses to pathogens. Divided into three classes …

Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The
study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling …

J. Clin. Invest. 109: 1271–1277 (2002). doi: 10.1172/JCI200215770. step in this pathway,
the transcription factor IFN regulatory factor 3 (IRF3) becomes phosphorylated on serine …

Interferons are a large family of multifunctional secreted proteins involved in antiviral
defense, cell growth regulation and immune activation. Viral infection induces transcription …

The three types of interferon (IFNs) are essential for immunity against at least some viruses
in the mouse model of experimental infections, type I IFNs displaying the broadest and …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …

The innate immune response is the major front line of defense against viral infections. It
involves hundreds of genes with antiviral properties which expression is induced by type I …

The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …