Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
Identification of cerebrospinal fluid (CSF) biomarkers of the common age-related
neurodegenerative diseases would be of great value to clinicians because of the difficulties …
neurodegenerative diseases would be of great value to clinicians because of the difficulties …
A combined dataset of human cerebrospinal fluid proteins identified by multi‐dimensional chromatography and tandem mass spectrometry
S Pan, D Zhu, JF Quinn, ER Peskind, TJ Montine… - …, 2007 - Wiley Online Library
Human cerebrospinal fluid (CSF) is an important source for studying protein biomarkers of
age‐related neurodegenerative diseases. Before characterizing biomarkers unique to each …
age‐related neurodegenerative diseases. Before characterizing biomarkers unique to each …
Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
Biomarkers to assist in the diagnosis and medical management of Alzheimer disease (AD)
are a pressing need. We have employed a proteomic approach, microcapillary liquid …
are a pressing need. We have employed a proteomic approach, microcapillary liquid …
Quantitative mass spectrometry analysis of cerebrospinal fluid protein biomarkers in Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of dementia, with cerebrospinal fluid
(CSF) β-amyloid (Aβ), total Tau, and phosphorylated Tau (pTau) providing the most sensitive …
(CSF) β-amyloid (Aβ), total Tau, and phosphorylated Tau (pTau) providing the most sensitive …
Proteome studies of CSF in AD patients
P Davidsson, M Sjögren - Mechanisms of ageing and development, 2006 - Elsevier
Proteins in cerebrospinal fluid (CSF) may often serve as indicators of neurodegenerative
diseases, and are a rich source for biomarker discovery. However, a large dynamic range of …
diseases, and are a rich source for biomarker discovery. However, a large dynamic range of …
Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease
RJ Perrin, R Craig-Schapiro, JP Malone, AR Shah… - PloS one, 2011 - journals.plos.org
Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …
CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels
Abstract Development of disease-modifying therapies against Alzheimer's disease (AD)
requires biomarkers reflecting the diverse pathological pathways specific for AD. We …
requires biomarkers reflecting the diverse pathological pathways specific for AD. We …
Characterization of proteome of human cerebrospinal fluid
J Xu, J Chen, ER Peskind, J Jin, J Eng, C Pan… - International Review of …, 2006 - Elsevier
Publisher Summary Human cerebrospinal fluid (CSF) is an ideal source for identifying
biomarkers for neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …
biomarkers for neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …
Proteomes of paired human cerebrospinal fluid and plasma: relation to blood–brain barrier permeability in older adults
The systems-level relationship between the proteomes of cerebrospinal fluid (CSF) and
plasma has not been comprehensively described so far. Recently developed shotgun …
plasma has not been comprehensively described so far. Recently developed shotgun …