Carbon-in-carbon: Hybrid carbonized nanomaterials with multifunctional activities for the treatment of endophthalmitis

HJ Jian, YR Chiou, A Anand, CF Chen, DHK Ma… - Chemical Engineering …, 2024 - Elsevier
Infectious endophthalmitis (EO) is a severe eye condition characterized by inflammation of
the eye's internal fluids and tissues, often resulting from infection by bacteria or fungi …

Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis

HY Lin, SW Wang, JY Mao, HT Chang… - Chemical Engineering …, 2021 - Elsevier
To prevent visual loss, clinical therapy of severe bacterial keratitis (BK) demands
simultaneous remedying of the damage caused by bacterial infection and its induced …

In situ hybridization of polymeric curcumin to arginine-derived carbon quantum dots for synergistic treatment of bacterial infections

HJ Jian, A Anand, JY Lai, B Unnikrishnan… - … Applied Materials & …, 2023 - ACS Publications
Effective infectious keratitis treatment must eliminate the pathogen, reduce the inflammatory
response, and prevent persistent damage to the cornea. Infectious keratitis is generally …

Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis

HJ Jian, RS Wu, TY Lin, YJ Li, HJ Lin, SG Harroun… - ACS …, 2017 - ACS Publications
We have developed a one-step method to synthesize carbon quantum dots (CQDPAs) from
biogenic polyamines (PAs) as an antibacterial agent for topical treatment of bacterial …

Construction of graphene quantum dot-based dissolving microneedle patches for the treatment of bacterial keratitis

Y Fang, L Zhuo, H Yuan, H Zhao, L Zhang - International Journal of …, 2023 - Elsevier
Bacterial keratitis (BK) is an ophthalmic infection caused by bacteria and poses a risk of
blindness. Numerous drugs have been used to treat BK, the majority suffered from limited …

Highly effective corneal permeability of reactive oxygen species-responsive nano-formulation encapsulated cyclosporine a for dry eye management

D Yang, Y Han, Y Wang, Y Pan, L Zheng, Z Liu… - Chemical Engineering …, 2023 - Elsevier
Dry eye disease (DED) has become a globally recognized public health problem with
complex pathogenesis. Recent studies showed that oxidative stress damage and its induced …

Antioxidant Carbon Dots Nanozyme Loaded in Thermosensitive in situ Hydrogel System for Efficient Dry Eye Disease Treatment

W Wei, H Cao, D Shen, X Sun, Z Jia… - International Journal of …, 2024 - Taylor & Francis
Purpose Dry eye disease (DED) is a multifactorial ocular surface disease with a rising
incidence. Therefore, it is urgent to construct a reliable and efficient drug delivery system for …

Antibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)

L Zhou, Y Deng, Y Ren, HL Poon, WY Chu… - Chemical Engineering …, 2024 - Elsevier
Bacterial keratitis (BK), which accounts for over 50% of the reported cases of microbial
keratitis, is a condition that can result in vision loss and blindness if left untreated. Antibiotics …

Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis

Y Bai, L Ma, Y Huang, S Lang, W Fan, G Liu - Biomaterials Science, 2023 - pubs.rsc.org
Inefficient biofilm clearance and the risk of drug resistance pose significant challenges for
antibiotic eye drops in the treatment of bacterial keratitis (BK). Recently, silver nanoparticles …

Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels

PH Lin, HJ Jian, YJ Li, YF Huang, A Anand, CC Huang… - Acta Biomaterialia, 2022 - Elsevier
Most dry eye syndromes (DES) are caused by oxidative stress and an overactive
inflammatory response, leading to tear deficiency and excessive tear evaporation …