The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also
include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these …

Several metals have been found to be carcinogenic to humans and/or animals (Tables 1
and 2). However, the underlying mechanisms remain unclear. It is believed that neoplastic …

This review presents and evaluates evidence relevant to the mechanisms of metal
carcinogenicity with special emphasis on the emerging hypothesis of the oxidative nature of …

Accumulating evidence demonstrates the ability of several carcinogenic metals tointeract
with and perma-nently alter the genetic components of living cells. The mechanisms of metal …

Mechanisms of carcinogenicity are discussed for metals and their compounds, classified as
carcinogenic to humans or considered to be carcinogenic to humans: arsenic, antimony …

Several metals have been found to be carcinogenic to humans and/or animals (Tables I and
II), but the mechanisms involved in the process of tumor formation by these metals remain …

The redox activity of metal ions can lead to the formation of highly reactive species that
damage DNA, producing different oxidation products and types of damage depending upon …

Metals are essential for the normal functioning of living organisms. Their uses in biological
systems are varied, but are frequently associated with sites of critical protein function, such …

Nickel, cadmium, cobalt, and arsenic compounds are well-known carcinogens to humans
and experimental animals. Even though their DNA-damaging potentials are rather weak …

The carcinogenicity and genotoxicity of cadmium, chromium, cobalt and nickel strongly
depend on their chemical ligands (speciation) which modulate their bioavailability and …