Establishment and validation of the Sprague-Dawley rat model of osteoarthritis with kidney deficiency and blood stagnation

C Yang, Y Li, H Jiao, M Shang, Q Liu, L Li… - Chinese Journal of …, 2024 - cjter.com
BACKGROUND: Kidney deficiency and blood stasis syndrome are common traditional
Chinese medicine syndromes observed in knee osteoarthritis, which serve as fundamental …

Establishment of a rat model of knee osteoarthritis with kidney deficiency and blood stagnation

Z Liu, R Fang - Chinese Journal of Tissue Engineering Research, 2013 - cjter.com
BACKGROUND: To establish a model of osteoarthritis with traditional Chinese medicine
syndromes is conductive to the syndrome differentiation studies. OBJECTIVE: To establish a …

Construction of a high intraosseous pressure type rabbit osteoarthritis model

QX Dai Qi-yi, J Yuan, G Lin, J Liu, P Ruan… - Chinese Journal of …, 2011 - cjter.com
BACKGROUND: Plenty of animal models of knee osteoarthritis has been established and
used, most of them may not be right for the experimental study of Chinese medicine …

Effect of Bushen Huoxue Decoction on the expression level of nuclear factor-KBp65 protein in chondrocytes of rabbit models of osteoporosis and osteoarthritis

B Zhang, K Zhang, W Ma, F Shen, H Chen - Chinese Journal of Tissue …, 2019 - cjter.com
BACKGROUND: Kidney deficiency and blood stasis are the common etiology and
pathogenesis of osteoarthritis and osteoporosis. The method of nourishing kidney and …

Treatment of knee osteoarthritis by tonifying kidney and spleen and activating blood circulation herbs via chondrocyte IL-1beta/ERR-alpha/SOX9/Col2alpha1 …

S Huo, H Wang, H Tang, Y Wang, Q Chen… - Chinese Journal of …, 2020 - cjter.com
BACKGROUND: Knee osteoarthritis is the most common degenerative joint disease with
high morbidity and disability, which severely threatens the life quality of patients. Chinese …

Degenerative knee osteoarthritis animal model and changes in intraosseous pressure during pathological processes

S Wang, Y Du, J Ma, Y Xue, W Liu, H Huang, L Zhang… - 2020 - researchsquare.com
Background Degenerative knee osteoarthritis (KOA) is a common clinical disease which
affecting patients' quality of life. However, there is currently no standard animal model for …

Experimental study on invigorating kidney and activating blood on preventing and curing SD rats with knee osteoarthritis

WF Ji, WF Shi, L Chen, ZC Ma, XF Yuan… - Zhongguo gu Shang …, 2012 - europepmc.org
Objective To explore the effects and mechanism of invigorating kidney and activating blood,
invigorating kidney and expelling wind on hemorheology, IL-1β and TNF-α of SD rats with …

Construction and pathological features of a rabbit osteoarthritis model in early, middle, and later phases

R Fang - Chinese Journal of Tissue Engineering Research, 2010 - cjter.com
BACKGROUND: Application of traditional osteoarthritis animal models was limited by long
duplicated time, poor stability, different successful rate, and rough analysis of osteoarthritis …

Preparation of rabbit models of surgically induced knee osteoarthritis

C Zhang, M Shen, L Chen, H Wang, Y Xiang… - Chinese Journal of …, 2023 - cjter.com
BACKGROUND: The two methods commonly used for preparing animal models of knee
osteoarthritis are surgical trauma and intra-articular injection of protease. However, the …

Experimental study on the intervention of renal tonifying and activating OPG/RANKL/RANK signaling pathway on steroid-induced femoral head necrosis

B Dong, J Yao, X Li, H Yu, W Kang, G Ou… - Osteoarthritis and …, 2019 - oarsijournal.com
Purpose: To explore the experimental study on the intervention of kidney-tonifying
OPG/RANKL/RANK signaling pathway on steroid-induced femoral head necrosis, laying a …