Chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to
inhibition of insulin secretion and apoptosis. Several previous studies have demonstrated …

Insulin-resistant states such as obesity can result in an increase in the function and mass of
pancreatic β-cells, so that insulin secretion is up-regulated and Type II diabetes does not …

Saturated and mono-unsaturated fatty acids exert differential effects on pancreatic β-cell
viability during chronic exposure. Long chain saturated molecules (eg palmitate) are …

Saturated fatty acids have been considered major contributing factors in type 2 diabetes,
whereas unsaturated fatty acids have beneficial effects for preventing the development of …

Chronic exposure of pancreatic β-cells to long-chain fatty acids can cause loss of secretory
function and enhanced apoptosis by a process of 'lipotoxicity', which may be a contributory …

Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and unsaturated fatty acids at different …

Long-chain saturated and monounsaturated fatty acids differ in their propensity to induce β-
cell death in vitro with palmitate (C16: 0) being cytotoxic, whereas palmitoleate (C16: 1n-7) …

Palmitate negatively affects insulin secretion and apoptosis in the pancreatic β‐cell. The
detrimental effects are abolished by elongating and desaturating the fatty acid into oleate. To …

We tested the effects of various types of fatty acids, differing in the degree of saturation and
in the cis/trans configuration of the double bond, on the growth and viability of NES2Y cells …

Hyperlipidemia is frequently associated with insulin resistance states as found in type 2
diabetes and obesity. Effects of free fatty acids (FFA) on pancreatic β‐cells have long been …