The past decade has seen an explosion in the identification of genetic causes of
neurodevelopmental disorders, including Mendelian, de novo, and somatic factors. These …

Neuropsychiatric research has been impeded by limited access to human brain tissue,
especially from early stages of neurodevelopment when the pathophysiology of many …

Neurological disorders are challenging to study given the complexity and species-specific
features of the organ system. Brain organoids are three dimensional structured aggregates …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

The development of the human brain occurs largely in utero over long periods of time and is
thus experimentally inaccessible; therefore, tractable experimental models are needed …

Human brain development is an intricate process that involves precisely timed coordination
of cell proliferation, fate specification, neuronal differentiation, migration, and integration of …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Processes associated with human brain development and function are exceedingly
complex, limiting our capacity to investigate disease status and potential treatment strategies …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …