Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis.
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …

Non-small cell lung cancer is the most common type of lung cancer. Both environmental and
genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide …

To find additional susceptibility loci for lung cancer, we tested promising associations from
our previous genome-wide association study (GWAS) of lung cancer in the Chinese …

Background: Prior genome-wide association studies have identified numerous lung cancer
risk loci and reveal substantial etiologic heterogeneity across histologic subtypes. Analyzing …

To explore the impact of common variation on the risk of developing lung cancer, we
conducted a two-phase genome-wide association (GWA) study. In phase 1, we compared …

Background Genetic variants and modifiable risk factors (including environmental exposure
and lifestyle) greatly contribute to the development of lung cancer. The population …

Asbestos exposure is a known risk factor for lung cancer. Although recent genome-wide
association studies (GWASs) have identified some novel loci for lung cancer risk, few …

Background: Tobacco-induced lung cancer is characterized by a deregulated inflammatory
microenvironment. Variants in multiple genes in inflammation pathways may contribute to …

Although dozens of susceptibility loci have been identified for lung cancer in genome-wide
association studies (GWASs), the susceptibility genes and underlying mechanisms remain …

An important follow-up step after genetic markers are found to be associated with a disease
outcome is a more detailed analysis investigating how the implicated gene or chromosomal …